The 26-year-old American, winner of eight Grand Slam titles, had pulled out of the event last year due to illness.
Serena Williams overcame a gritty challenge from unseeded Dutchwoman Kiki Bertens, winning 7-6(7), 6-4, to reach the French Open final, in Paris, on Friday. She will meet Garbine Muguruza, who reached her second Grand Slam final when she beat Australia's Samantha Stosur 6-2, 6-4 in the first semi-final at Roland Garros.
Australian Samantha Stosur pulled off a stunning 6-2, 6-7, 8-6 victory over top seed Serena Williams on Wednesday to reach the semi-finals of the French Open for the second year in succession.
Serena Williams, through sheer force of will as much as her unquestionable skill, beat world number one Victoria Azarenka 6-2, 2-6, 7-5 in a dramatic US Open final on Sunday to win her fourth title at Flushing Meadows and her 15th career Grand Slam.
Top-ranked Serena Williams suffered a shock 6-4, 6-4 loss to Slovakia's world number 78 Jana Cepelova in the second round of the Family Circle Cup on Tuesday.
Images from the Miami Open matches played on Saturday.
Serena Williams weathered an early challenge from Russian Vera Zvonareva before the former World No 2 crumbled to lose 7-5, 6-0 in the second round of the Australian Open on Thursday.
A resurgent Serena Williams overcame a strong challenge from fellow-American Meghann Shaughnessy, winning 6-7, 6-1, 6-4.
However, French Open champion Anastasia Myskina's run of miserable form continued when she was beaten by Switzerland's Patty Schnyder.
The former world No 1's second round victory set up a quarter-final meeting with Russia's Anastasia Rodionova at the Bangalore Open.
Serena Williams could wow the Wimbledon public next year by reviving her skin-tight, all-in-one catsuit in white.
Roger Federer and Serena Williams booked a second round berth, while Robin Soderling was booted out, during the Australian Open on Tuesday.
Once a beaming Anisimova had lifted herself off the ground, she scooped up her three-year-old nephew Jackson for a victory lap.
Serena Williams will make her long-awaited return to the Arthur Ashe centre court on Tuesday when she opens her latest US Open campaign against Bojana Jovanovski.
Serena Williams pulled out of next week's Nasdaq Open in Miami on Friday, citing a knee injury and lack of training.
A battle-tested Serena Williams booked her spot in the semi-finals of the Toronto Cup on Friday after overcoming a sluggish start to grind out a 4-6, 6-3, 6-2 win over Czech Lucie Safarova.
It has been 14 years since Serena Williams won her first US Open but there was no hint of decline as the 31-year-old American outlasted Victoria Azarenka to claim her fifth US Open singles title on Sunday.
Daniela Hantuchova said that Serena did not need the medical-timeout during their third-round match.
Venus worde down Lindsay Davenport while Clijsters rallied to beat Silvia Farina Elia in women's quarter-final matches.
Canadian teenager Eugenie Bouchard swatted aside an out-of-sorts Serena Williams 6-2, 6-1 at the Hopman Cup in Perth on Tuesday.
It is unlikely that Alize Cornet will ever forget the moment she watched Serena Williams come charging towards the net - only to whip a backhand straight into the barrier.
With her post-pregnancy comeback, the tennis champ is shattering stereotypes and inspiring women everywhere.
A round-up of the important matches at Wimbledon on Friday.
German Sabine Lisicki sent another seismic shockwave through Wimbledon on Monday when she sent five-times champion Serena Williams packing in fourth round, while Li Na and Petra Kvitova advanced to the quarter-finals.
'I don't know. It's tough to explain my emotion right now. Maybe tomorrow morning I can tell you something, but now it's amazing'
Wimbledon champions Roger Federer and Serena Williams were on course for further success at the All-England Club after booking their places in the Olympic singles semi-finals on Thursday.
Serena Williams is prepared to go without another victory this year, as long as she mounts a successful title defence at next week's U.S. Open.
Serena Williams has used her painful defeat at the French Open to spur her on at Wimbledon.\n\n
World number two Serena Williams brushed aside qualifier Lucie Safarova 6-3, 6-2 on Friday to reach the semi-finals of the Toronto Cup and set up a mouth-watering clash with Elena Dementieva.
Victoria Azarenka suffered a stunning meltdown and blew three match points against world number one Serena Williams before losing 7-6(5), 3-6, 7-6(1) in the third round of the Madrid Open on Wednesday.
French Open champion Justine Henin enjoyed a swift 60-minute workout to overcome Russia's Vera Dushevina to enter the third round.
Serena Williams, who racked up her 500th match win with the victory, said her ankle is still causing her problems, a potential issue for tougher tests ahead.
Tennis World No. 1 Serena Williams found herself in trouble with security officials at the PGA Tour's Honda Classic on Friday after she tried to photograph Tiger Woods.
Former World No. 1 Serena Williams gave the United States a commanding 2-0 lead over Belarus in their Fed Cup tie on Saturday after top ranked Victoria Azarenka was unable to compete for the eastern Europeans because of a sore lower back.
Breeze though the outfits that caught the maximum shutterbugs at the final Grand Slam of the year.
Serena Williams started her 2010 season in the same devastating fashion in which she ended 2009, thrashing Spain's Marie Jose Martinez Sanchez 6-1, 6-2 in the second round of the Sydney International on Tuesday.
